abstract：:The effect of PF-04457845, a potent and selective fatty acid amide hydrolase-1 (FAAH1) inhibitor, on pain due to osteoarthritis of the knee was investigated in a randomised placebo and active-controlled clinical trial. The trial involved 2 periods (separated by a 2-week washout) consisting of a 1-week wash-in phase fo...

journal_title：Pain

authors： Huggins JP,Smart TS,Langman S,Taylor L,Young T

更新日期：2012-09-01 00:00:00

abstract：:Numerous behavioral pain measures have been validated for young children, but none is appropriate to assess pain in emergency departments (EDs), where caregivers need a simple, easily completed scale. Our objective was to elaborate and validate a tool, relevant in any painful situation, with agitation or prostration, ...

journal_title：Pain

authors： Fournier-Charrière E,Tourniaire B,Carbajal R,Cimerman P,Lassauge F,Ricard C,Reiter F,Turquin P,Lombart B,Letierce A,Falissard B

更新日期：2012-08-01 00:00:00

abstract：:Heterotopic noxious counterstimulation (HNCS) by the application of a sustained noxious stimulus has been shown to inhibit nociceptive processes and decrease pain induced by a competing noxious stimulus. However, it is still not clear how attentional processes contribute to these effects. The main objective of this st...

journal_title：Pain

authors： Ladouceur A,Tessier J,Provencher B,Rainville P,Piché M

更新日期：2012-08-01 00:00:00

abstract：:Patients suffering from postherpetic neuralgia often complain about hypo- or hypersensation in the affected dermatome. The loss of thermal sensitivity has been demonstrated by quantitative sensory testing as being associated with small-fiber (Aδ- and C-fiber) deafferentation. We aimed to compare laser stimulation (rad...

journal_title：Pain

authors： Franz M,Spohn D,Ritter A,Rolke R,Miltner WHR,Weiss T

更新日期：2012-08-01 00:00:00

abstract：:Individual differences in interoceptive sensitivity are associated with differences in reported intensity of emotional experience, vulnerability to anxiety and mood disorder and capacity for emotional self-regulation. Enhanced sensitivity to autonomic state is often accompanied by increased autonomic reactivity. Here ...

journal_title：Pain

authors： Pollatos O,Füstös J,Critchley HD

更新日期：2012-08-01 00:00:00

abstract：:Inflammatory thermal hyperalgesia is principally mediated through transient receptor potential vanilloid 1 (TRPV1) channels, as demonstrated by prior studies using models of cutaneous inflammation. Muscle pain is significantly different from cutaneous pain, and the involvement of TRPV1 in hyperalgesia induced by muscl...

journal_title：Pain

authors： Walder RY,Radhakrishnan R,Loo L,Rasmussen LA,Mohapatra DP,Wilson SP,Sluka KA

更新日期：2012-08-01 00:00:00

abstract：:Procedural pain is associated with poorer neurodevelopment in infants born very preterm (≤ 32 weeks gestational age), however, the etiology is unclear. Animal studies have demonstrated that early environmental stress leads to slower postnatal growth; however, it is unknown whether neonatal pain-related stress affects ...

journal_title：Pain

authors： Vinall J,Miller SP,Chau V,Brummelte S,Synnes AR,Grunau RE

更新日期：2012-07-01 00:00:00

abstract：:Laser-evoked potentials (LEPs) are acknowledged as the most reliable laboratory tool for assessing thermal and pain pathways. Electrical stimulation with a newly developed planar concentric electrode, delivering stimuli limited to the superficial skin layers, has been suggested to provide selective activation of Aδ fi...

journal_title：Pain

authors： Perchet C,Frot M,Charmarty A,Flores C,Mazza S,Magnin M,Garcia-Larrea L

更新日期：2012-06-01 00:00:00

abstract：:Serotonin is critically involved in neuropathic pain. However, its role is far from being understood owing to the number of cellular targets and receptor subtypes involved. In a rat model of neuropathic pain evoked by chronic constriction injury (CCI) of the sciatic nerve, we studied the role of 5-HT(2B) receptor in d...

journal_title：Pain

authors： Urtikova N,Berson N,Van Steenwinckel J,Doly S,Truchetto J,Maroteaux L,Pohl M,Conrath M

更新日期：2012-06-01 00:00:00

abstract：:A number of pharmacologic treatments examined in recent randomized clinical trials (RCTs) have failed to show statistically significant superiority to placebo in conditions in which their efficacy had previously been demonstrated. Assuming the validity of previous evidence of efficacy and the comparability of the pati...

journal_title：Pain

authors： Dworkin RH,Turk DC,Peirce-Sandner S,Burke LB,Farrar JT,Gilron I,Jensen MP,Katz NP,Raja SN,Rappaport BA,Rowbotham MC,Backonja MM,Baron R,Bellamy N,Bhagwagar Z,Costello A,Cowan P,Fang WC,Hertz S,Jay GW,Junor R,Ker

更新日期：2012-06-01 00:00:00

abstract：:An abundance of animal research suggests that fear inhibits pain whereas anxiety increases it. Human studies on this topic are more scarce, and the existing evidence seems rather inconsistent. Therefore, we aimed to investigate the divergent effects of both negative emotional states-that is, pain-related fear and anxi...

journal_title：Pain

authors： Meulders A,Vansteenwegen D,Vlaeyen JWS

更新日期：2012-05-01 00:00:00

abstract：:Multidimensional models of pain processing distinguish the sensory, motivational, and affective components of the pain experience. Efforts to understand underlying mechanisms have focused on isolating the roles of specific brain structures, including both limbic and non-limbic cortical areas, in the processing of noci...

journal_title：Pain

authors： Uhelski ML,Davis MA,Fuchs PN

更新日期：2012-04-01 00:00:00

abstract：:This study evaluated movement velocity, frequency, and amplitude, as well as the number of arrests in three different subject groups, by kinematic analysis of repetitive movements during a finger tapping (FT) task. The most affected hands of 80 patients with complex regional pain syndrome (CRPS) were compared with the...

journal_title：Pain

authors： Schilder JCM,Schouten AC,Perez RSGM,Huygen FJPM,Dahan A,Noldus LPJJ,van Hilten JJ,Marinus J

更新日期：2012-04-01 00:00:00

abstract：:In children, many psychometric properties of the visual analogue scale (VAS) are known, including the minimum clinically significant difference (10mm on a 100-mm VAS). However, its imprecision or reliability is not well known. Thus, in order to determine the reliability of this scale, a prospective cohort study was pe...

journal_title：Pain

authors： Bailey B,Gravel J,Daoust R

更新日期：2012-04-01 00:00:00

abstract：:Potential applications of attention bias modification (ABM) for acute and chronic pain patients are investigated. In study 1, 54 acute back pain patients (46 of whom completed the study) were recruited at their initial physiotherapy session and randomised to receive 1 session of ABM or placebo. Patients were followed ...

journal_title：Pain

authors： Sharpe L,Ianiello M,Dear BF,Perry KN,Refshauge K,Nicholas MK

更新日期：2012-03-01 00:00:00

abstract：:Chronic compression of rat dorsal root ganglion (CCD) produced tactile allodynia accompanied with hyperexcitability of the myelinated Aβ dorsal root ganglion (DRG) neurons. The Aβ DRG neuron hyperexcitability exhibits as bursting discharges in response to peripherally evoked action potentials (evoked bursting [EB]). T...

journal_title：Pain

authors： Song Y,Li HM,Xie RG,Yue ZF,Song XJ,Hu SJ,Xing JL

更新日期：2012-03-01 00:00:00

abstract：:Internet-based educational and therapeutic programs (e-health applications) are becoming increasingly popular for a variety of psychological and physical disorders. We tested the efficacy of an online Chronic Pain Management Program, a comprehensive, fully self-directed and self-paced system that integrates social net...

journal_title：Pain

authors： Ruehlman LS,Karoly P,Enders C

更新日期：2012-02-01 00:00:00

abstract：:We performed a prospective study in 32 patients with Guillain-Barré syndrome (GBS) or its variants to correlate intraepidermal nerve fiber density (IENFD) at the distal leg and lumbar region with pain, autonomic dysfunction, and outcome. In the acute phase, IENFD was reduced in 60% and 61.9% of patients at the distal ...

journal_title：Pain

authors： Ruts L,van Doorn PA,Lombardi R,Haasdijk ED,Penza P,Tulen JHM,Hempel RJ,van den Meiracker AH,Lauria G

更新日期：2012-02-01 00:00:00

abstract：:The facial expression of pain plays a crucial role in pain communication and pain diagnostics. Despite its importance, it has remained unknown which dimensions of pain (sensory and/or affective) are encoded in the face. To answer this question, we used a well-established cognitive strategy (suggestions) to differentia...

journal_title：Pain

authors： Kunz M,Lautenbacher S,LeBlanc N,Rainville P

更新日期：2012-02-01 00:00:00

abstract：:Ziconotide is a nonopioid intrathecal analgesic drug used to manage moderate to severe chronic pain. The aim of this work is to assess the safety and efficacy of intrathecal (IT) combination of ziconotide and morphine in malignant pain refractory to high doses of oral opioids. Patients with malignant pain refractory t...

journal_title：Pain

authors： Alicino I,Giglio M,Manca F,Bruno F,Puntillo F

更新日期：2012-01-01 00:00:00

abstract：:Investigating dose-dependent effects of placebo analgesia (PA) in laboratory subjects undergoing pain testing, we evaluated 2 hypotheses: (1) greater expectancy for relief produces greater PA, and (2) cued expectancy for relief triggered by a predictive cue leads to more enhanced analgesia than does passive expectancy...

journal_title：Pain

authors： Nakamura Y,Donaldson GW,Kuhn R,Bradshaw DH,Jacobson RC,Chapman RC

更新日期：2012-01-01 00:00:00

abstract：:The aim of this study was to test the capacity of the Fear Avoidance Model to explain the relationship between pain and disability in patients with whiplash-associated disorders. Using the method of Baron and Kenny, we assessed the mediating effect of fear of movement on the cross-sectional and longitudinal relationsh...

journal_title：Pain

authors： Kamper SJ,Maher CG,Menezes Costa LDC,McAuley JH,Hush JM,Sterling M

更新日期：2012-01-01 00:00:00

abstract：:Adolescents with chronic pain are at risk for impairment in their friendships. They miss out on leisure activities, have increased school absence, may have fewer friends, are at an increased risk for victimization, and may be perceived by peers as less likeable. To help determine the source of these problems, the Soci...

journal_title：Pain

authors： Forgeron PA,McGrath P,Stevens B,Evans J,Dick B,Finley AG,Carlson T

更新日期：2011-12-01 00:00:00

abstract：:A systematic review and meta-analysis of population-based epidemiological studies was undertaken to determine the prevalence of foot and ankle pain in middle and old age. Searches were conducted in the following electronic databases from inception to October 2010: PubMed, EMBASE, AMED, CINAHL, Cochrane, PEDro, and Spo...

journal_title：Pain

authors： Thomas MJ,Roddy E,Zhang W,Menz HB,Hannan MT,Peat GM

更新日期：2011-12-01 00:00:00

abstract：:Complex regional pain syndrome (CRPS) is a painful condition affecting one or more extremities of the body, marked by a wide variety of symptoms and signs that are often difficult to manage because the pathophysiology is incompletely understood. Thus, diverse treatments might be ineffective. A recent report revealed t...

journal_title：Pain

authors： Kohr D,Singh P,Tschernatsch M,Kaps M,Pouokam E,Diener M,Kummer W,Birklein F,Vincent A,Goebel A,Wallukat G,Blaes F

更新日期：2011-12-01 00:00:00

abstract：:Studies in the literature do not show clear evidence supporting the relationship between pain and depressive symptoms in individuals experiencing acute/subacute pain compared to those experiencing chronic pain. However, more information is needed about which variables act as mediators in the pain-depression relationsh...

journal_title：Pain

authors： Corbière M,Zaniboni S,Coutu MF,Franche RL,Guzman J,Dawson K,Yassi A

更新日期：2011-11-01 00:00:00

abstract：:Managing acute procedural pain effectively in preterm infants in the neonatal intensive care unit remains a significant problem. The objectives of this study were to evaluate the efficacy of breastfeeding for reducing pain and to determine if breastfeeding skills were altered after this treatment. Fifty-seven infants ...

journal_title：Pain

authors： Holsti L,Oberlander TF,Brant R

更新日期：2011-11-01 00:00:00

abstract：:Chronic pain in adults has been associated with early-life stress. To examine the pronociceptive effect of early-life stress, we evaluated cutaneous and muscle nociception and activity in muscle nociceptors in an animal model of neonatal stress, limited bedding, in the rat. In this neonatal limited bedding (NLB) model...

journal_title：Pain

authors： Green PG,Chen X,Alvarez P,Ferrari LF,Levine JD

更新日期：2011-11-01 00:00:00

abstract：:Chronic neuropathic pain is associated with long-term changes at multiple levels of the neuroaxis, including in the brain, where electrical stimulation has been used to manage severe pain conditions. However, the clinical outcome of deep brain stimulation is often mixed, and the mechanisms are poorly understood. By me...

journal_title：Pain

authors： Iwata M,LeBlanc BW,Kadasi LM,Zerah ML,Cosgrove RG,Saab CY

更新日期：2011-11-01 00:00:00

abstract：:Venoms peptides have produced exceptional sources for drug development to treat pain. In this study we examined the antinociceptive and side effects of Tx3-3, a peptide toxin isolated from Phoneutria nigriventer venom, which inhibits high-voltage-dependent calcium channels (VDCC), preferentially P/Q and R-type VDCC. W...

journal_title：Pain

authors： Dalmolin GD,Silva CR,Rigo FK,Gomes GM,do Nascimento Cordeiro M,Richardson M,Silva MAR,Prado MAM,Gomez MV,Ferreira J

更新日期：2011-10-01 00:00:00

abstract：:To date, patients with bony metastases were only a small fraction of the samples studied, or they were entirely excluded. Patients with metastatic cancers, such as bone metastases, are more likely to report pain, compared to patients without metastatic cancer (50-74% and 15%, respectively). Their cancer pain results i...

journal_title：Pain

authors： Jane SW,Chen SL,Wilkie DJ,Lin YC,Foreman SW,Beaton RD,Fan JY,Lu MY,Wang YY,Lin YH,Liao MN

更新日期：2011-10-01 00:00:00

abstract：:Studies on the efficacy of ketamine in the treatment of chronic pain indicate that prolonged or repetitive infusions are required to ensure prolonged pain relief. Few studies address ketamine-induced toxicity. Here we present data on the occurrence of ketamine-induced liver injury during repeated administrations of S(...

journal_title：Pain

authors： Noppers IM,Niesters M,Aarts LPHJ,Bauer MCR,Drewes AM,Dahan A,Sarton EY

更新日期：2011-09-01 00:00:00

abstract：:Data on comparative safety of opioid analgesics are limited, but some reports suggest disproportionate mortality risk associated with methadone. Our objective was to compare mortality rates among patients who received prescribed methadone or long-acting morphine for pain. This is a retrospective observational cohort d...

journal_title：Pain

authors： Krebs EE,Becker WC,Zerzan J,Bair MJ,McCoy K,Hui S

更新日期：2011-08-01 00:00:00

abstract：:Growth mixture modeling (GMM) identified latent groups based on treatment outcome trajectories of headache disability measures in patients in headache subspecialty treatment clinics. Using a longitudinal design, 219 patients in headache subspecialty clinics in 4 large cities throughout Ohio provided data on their head...

journal_title：Pain

authors： Lewis KN,Heckman BD,Himawan L

更新日期：2011-08-01 00:00:00

abstract：:The neuropeptide bradykinin (BK) sensitizes nociceptor activation following its release in response to inflammatory injury. Thereafter, the bioactivity of bradykinin is controlled by the enzymatic activities of circulating peptidases. One such enzyme, the metalloendopeptidase EC3.4.24.15 (EP24.15), is co-expressed wit...

journal_title：Pain

authors： Gomez R,Por ED,Berg KA,Clarke WP,Glucksman MJ,Jeske NA

更新日期：2011-07-01 00:00:00

abstract：:Transient receptor potential ion channel melastatin subtype 8 (TRPM8) is activated by cold temperatures and cooling agents, such as menthol and icilin. Compounds containing peppermint are reported to reduce symptoms of bowel hypersensitivity; however, the underlying mechanisms of action are unclear. Here we determined...

journal_title：Pain

authors： Harrington AM,Hughes PA,Martin CM,Yang J,Castro J,Isaacs NJ,Blackshaw AL,Brierley SM

更新日期：2011-07-01 00:00:00

abstract：:We assessed for the first time the long-term maintenance of repetitive transcranial magnetic stimulation (rTMS)-induced analgesia in patients with chronic widespread pain due to fibromyalgia. Forty consecutive patients were randomly assigned, in a double-blind fashion, to 2 groups: one receiving active rTMS (n=20) and...

journal_title：Pain

authors： Mhalla A,Baudic S,de Andrade DC,Gautron M,Perrot S,Teixeira MJ,Attal N,Bouhassira D

更新日期：2011-07-01 00:00:00

abstract：:Distinct developmental trajectories for neck disability and posttraumatic stress disorder (PTSD) symptoms after whiplash injury have recently been identified. This study aimed to identify baseline predictors of membership to these trajectories and to explore their dual development. In a prospective study, 155 individu...

journal_title：Pain

authors： Sterling M,Hendrikz J,Kenardy J

更新日期：2011-06-01 00:00:00

abstract：:This study compared individuals with fibromyalgia (FM) and individuals with chronic low back pain (CLBP) on repetition-induced summation of activity-related pain (RISP). Fear of movement, pain catastrophizing and depression were examined as potential mediators of group differences. The sample consisted of 50 women wit...

journal_title：Pain

authors： Lambin DI,Thibault P,Simmonds M,Lariviere C,Sullivan MJL

更新日期：2011-06-01 00:00:00

abstract：:Contrary to a clinical aphorism that early head and neck cancer is painless, we show that patients who develop head and neck cancer experience significant pain at the time of initial diagnosis. We compared orofacial pain sensitivity in groups of patients with normal oral mucosa, oral precancer, and newly diagnosed ora...

journal_title：Pain

authors： Lam DK,Schmidt BL

更新日期：2011-05-01 00:00:00